中文别名:16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-醋酸酯;醋酸地塞米松;21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮;9α-氟-11β,17α,21-三羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮-21-醋酸酯;醋酸氟甲强的松龙;醋酸氟美松;醋酸甲氟烯索;地塞米松醋酸酯
英文别名:1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE; 9a-fluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate; 9 ALPHA-FLUORO-11 BETA,17 ALPHA,21-TRIHYDRO-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-ACETATE; 9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE-21-ACETATE; 9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA,17-ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE ACETATE; 9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE-21-ACETATE; DEXAMETHASON ACETATE; dexamethasone-17-acetate; DEXAMETHASONE 21-ACETATE; DEXAMETHASONE ACETATE; PREDNISOLONE F ACETATE; ,(11beta,16alpha)-; 16alpha-Methyl-9alpha-fluoroprednisolone 21-acetate; 20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-pregna-4-diene-3; 20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-pregna-4-diene-3; 9alpha-Fluoro-16alpha-methylprednisolone acetate; 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-acetate; 9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate; 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-acetate
熔点 215-227℃
折射率 87 ° (C=1, Dioxane)
外观性状 白色或类白色结晶性粉末,无臭,味微苦
溶解性 丙酮中易溶,在甲醇或乙醇中溶解,在乙醇或氯仿中略溶,在乙醚中极微溶解,在水中不溶
倍他米松、地塞米松磷酸钠的中间体。用于抗炎和抗过敏,适用于类风湿性关节炎和其他胶原性疾病等。
可用16α,17α-环氧孕甾-4-烯-3,11,20-三酮(即16α,17α-环氧-11-酮基黄体酮)经(3-位、20-位酮基)缩酮化、(11-位酮基)还原、消除[9(11)-位脱水形成双键]、(环氧基与甲基溴化镁)加成并水解(形成17α-羟基,16β-甲基)、水解(脱除乙二醇)得17α-羟基-16β-甲基孕甾-4,9(11)-二烯-3,20-二酮,然后经(4、5-位)脱氢(形成双键)、(21-位)碘化、(21-位碘经乙酰氧基)置换,[9(11)-位双键与次溴酸]加成、[9(11)-位]环氧化、9(11)位氟化氢加成后制得该品。